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Propofol Causes Vasodilation In Vivo via TRPA1 Ion Channels: Role of Nitric Oxide and BK(Ca) Channels

BACKGROUND: Transient receptor potential (TRP) ion channels of the A1 (TRPA1) and V1 (TRPV1) subtypes are key regulators of vasomotor tone. Propofol is an intravenous anesthetic known to cause vasorelaxation. Our objectives were to examine the extent to which TRPA1 and/or TRPV1 ion channels mediate...

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Publicat a:PLoS One
Autors principals: Sinha, Sayantani, Sinharoy, Pritam, Bratz, Ian N., Damron, Derek S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382130/
https://ncbi.nlm.nih.gov/pubmed/25830814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122189
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