Ghrelin Increases Beta-Catenin Level through Protein Kinase A Activation and Regulates OPG Expression in Rat Primary Osteoblasts

Ghrelin, by binding growth hormone secretagogue receptor (GHS-R), promotes osteoblast proliferation but the signaling mechanism of GHS-R on these cells remains unclear. Since canonical Wnt/β-catenin pathway is critically associated with bone homeostasis, we investigated its involvement in mediating...

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Detalhes bibliográficos
Publicado no:Int J Endocrinol
Main Authors: Mrak, Emanuela, Casati, Lavinia, Pagani, Francesca, Rubinacci, Alessandro, Zarattini, Guido, Sibilia, Valeria
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381660/
https://ncbi.nlm.nih.gov/pubmed/25866509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/547473
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