Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study

INTRODUCTION: The antidiabetic drug metformin exhibits potential anticancer properties that are believed to involve both direct (insulin-independent) and indirect (insulin-dependent) actions. Direct effects are linked to activation of AMP-activated protein kinase (AMPK) and an inhibition of mammalia...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Dowling, Ryan JO, Niraula, Saroj, Chang, Martin C, Done, Susan J, Ennis, Marguerite, McCready, David R, Leong, Wey L, Escallon, Jaime M, Reedijk, Michael, Goodwin, Pamela J, Stambolic, Vuk
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381495/
https://ncbi.nlm.nih.gov/pubmed/25849721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-015-0540-0
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