Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism

AIMS: High-fat diet-induced obesity (DIO) is a major contributor to type II diabetes and micro- and macro-vascular complications leading to peripheral vascular disease (PVD). Metabolic abnormalities of induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) from obese individuals could po...

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Détails bibliographiques
Publié dans:Eur Heart J
Auteurs principaux: Gu, Mingxia, Mordwinkin, Nicholas M., Kooreman, Nigel G., Lee, Jaecheol, Wu, Haodi, Hu, Shijun, Churko, Jared M., Diecke, Sebastian, Burridge, Paul W., He, Chunjiang, Barron, Frances E., Ong, Sang-Ging, Gold, Joseph D., Wu, Joseph C.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Basic Science
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381134/
https://ncbi.nlm.nih.gov/pubmed/25368203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehu411
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