Leucine-Rich Repeat Kinase 2 Modulates Neuroinflammation and Neurotoxicity in Models of Human Immunodeficiency Virus 1-Associated Neurocognitive Disorders

Leucine-rich repeat kinase 2 (LRRK2) is the single most common genetic cause of both familial and sporadic Parkinson's disease (PD), both of which share pathogenetic and neurologic similarities with human immunodeficiency virus 1 (HIV-1)-associated neurocognitive disorders (HAND). Pathologic LR...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Puccini, Jenna M., Marker, Daniel F., Fitzgerald, Tim, Barbieri, Justin, Kim, Christopher S., Miller-Rhodes, Patrick, Lu, Shao-Ming, Dewhurst, Stephen, Gelbard, Harris A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381000/
https://ncbi.nlm.nih.gov/pubmed/25834052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0650-14.2015
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