Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis

Genetic screens are powerful tools for identifying genes responsible for diverse phenotypes. Here we describe a genome-wide CRISPR-Cas9-mediated loss-of-function screen in tumor growth and metastasis. We mutagenized a non-metastatic mouse cancer cell line using a genome-scale library with 67,405 sin...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell
Päätekijät: Chen, Sidi, Sanjana, Neville E., Zheng, Kaijie, Shalem, Ophir, Lee, Kyungheon, Shi, Xi, Scott, David A., Song, Jun, Pan, Jen Q., Weissleder, Ralph, Lee, Hakho, Zhang, Feng, Sharp, Phillip A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380877/
https://ncbi.nlm.nih.gov/pubmed/25748654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.02.038
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