Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions(1,2) (www.T1DBase.org) revealing major pathways contributing to risk(3), with some loci shared across immune disorders(4–6). In order to make genetic comparisons across autoimmune disorders as informative as possible...

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Publicado no:Nat Genet
Main Authors: Onengut-Gumuscu, Suna, Chen, Wei-Min, Burren, Oliver, Cooper, Nick J., Quinlan, Aaron R., Mychaleckyj, Josyf C., Farber, Emily, Bonnie, Jessica K., Szpak, Michal, Schofield, Ellen, Achuthan, Premanand, Guo, Hui, Fortune, Mary D., Stevens, Helen, Walker, Neil M., Ward, Luke D., Kundaje, Anshul, Kellis, Manolis, Daly, Mark J., Barrett, Jeffrey C., Cooper, Jason D., Deloukas, Panos, Todd, John A., Wallace, Chris, Concannon, Patrick, Rich, Stephen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380767/
https://ncbi.nlm.nih.gov/pubmed/25751624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3245
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