Prediction of Overall In Vitro Microsomal Stability of Drug Candidates Based on Molecular Modeling and Support Vector Machines. Case Study of Novel Arylpiperazines Derivatives

Other than efficacy of interaction with the molecular target, metabolic stability is the primary factor responsible for the failure or success of a compound in the drug development pipeline. The ideal drug candidate should be stable enough to reach its therapeutic site of action. Despite many recent...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Ulenberg, Szymon, Belka, Mariusz, Król, Marek, Herold, Franciszek, Hewelt-Belka, Weronika, Kot-Wasik, Agata, Bączek, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380424/
https://ncbi.nlm.nih.gov/pubmed/25826401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122772
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