Prediction of Overall In Vitro Microsomal Stability of Drug Candidates Based on Molecular Modeling and Support Vector Machines. Case Study of Novel Arylpiperazines Derivatives

Other than efficacy of interaction with the molecular target, metabolic stability is the primary factor responsible for the failure or success of a compound in the drug development pipeline. The ideal drug candidate should be stable enough to reach its therapeutic site of action. Despite many recent...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Ulenberg, Szymon, Belka, Mariusz, Król, Marek, Herold, Franciszek, Hewelt-Belka, Weronika, Kot-Wasik, Agata, Bączek, Tomasz
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380424/
https://ncbi.nlm.nih.gov/pubmed/25826401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122772
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