KRAS Mutation and Microsatellite Instability: Two Genetic Markers of Early Tumor Development That Influence the Prognosis of Colorectal Cancer

INTRODUCTION: We examined two genetic markers established early in colorectal tumor development, microsatellite instability (MSI) and mutation of the KRAS proto-oncogene, to see if these genetic changes influence metastatic disease progression and survival. PATIENTS AND METHODS: MSI and KRAS mutatio...

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Dettagli Bibliografici
Pubblicato in:Ann Surg Oncol
Autori principali: Nash, Garrett M., Gimbel, Mark, Cohen, Alfred M., Zeng, Zhao-Shi, Ndubuisi, Mackevin I., Nathanson, Daniel R., Ott, Jurg, Barany, Francis, Paty, Philip B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380015/
https://ncbi.nlm.nih.gov/pubmed/19813061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-009-0713-0
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