Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice

INTRODUCTION: Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity that has oncosuppressive actions in numerous tumor types. METHODS: We have intercrossed Mmp8-null mice with the Polyoma virus middle T oncogene-driven (MMTV-PyMT) mouse model of mamm...

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Vydáno v:Breast Cancer Res
Hlavní autoři: Decock, Julie, Hendrickx, Wouter, Thirkettle, Sally, Gutiérrez-Fernández, Ana, Robinson, Stephen D, Edwards, Dylan R
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380014/
https://ncbi.nlm.nih.gov/pubmed/25848906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-015-0545-8
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