Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein

Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor disturbances. Various pathogenic pathways drive disease progression including oxidative stress, mitochondrial dysfunction, α-synuclein aggregation and impairment of protein degradation systems. Dysfunction...

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Detalhes bibliográficos
Publicado no:Front Behav Neurosci
Main Authors: Bentea, Eduard, Van der Perren, Anke, Van Liefferinge, Joeri, El Arfani, Anissa, Albertini, Giulia, Demuyser, Thomas, Merckx, Ellen, Michotte, Yvette, Smolders, Ilse, Baekelandt, Veerle, Massie, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379937/
https://ncbi.nlm.nih.gov/pubmed/25873870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2015.00068
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