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DJ-1 Knockout Augments Disease Severity and Shortens Survival in a Mouse Model of ALS
Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, neurodegenerative disorder, characterized by the degeneration of motor neurons. Oxidative stress plays a central role in the disease progression, in concert with an enhanced glutamate excitotoxicity and neuroinflammation. DJ-1 mutations,...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4379040/ https://ncbi.nlm.nih.gov/pubmed/25822630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117190 |
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