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Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity

DNA double strand break (DSB) is one of the major damages that cause genome instability and cellular aging. The homologous recombination (HR)-mediated repair of DSBs plays an essential role in assurance of genome stability and cell longevity. Telomeres resemble DSBs and are competent for HR. Here we...

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Detaylı Bibliyografya
Yayımlandı:PLoS Genet
Asıl Yazarlar: Peng, Jing, He, Ming-Hong, Duan, Yi-Ming, Liu, Yu-Ting, Zhou, Jin-Qiu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378880/
https://ncbi.nlm.nih.gov/pubmed/25822194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005071
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