Downregulation of DNA Methyltransferase 1 in Zona-Free Cloned Buffalo (Bubalus bubalis) Embryos by Small Interefering RNA Improves In Vitro Development But Does Not Alter DNA Methylation Level

Aberrant epigenetic reprogramming, especially genomic hypermethylation, is implicated as the primary reason behind the failure of the cloning process during somatic cell nuclear transfer (SCNT). We transfected one-cell-stage zona-free buffalo embryos produced by handmade cloning with 50 nM DNMT1 sma...

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Publicat a:Cell Reprogram
Autors principals: Selokar, Naresh L., Saini, Monika, Agrawal, Himanshu, Palta, Prabhat, Chauhan, Manmohan S., Manik, Radheysham, Singla, Suresh K.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2015
Matèries:
Brief Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378840/
https://ncbi.nlm.nih.gov/pubmed/25826721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cell.2014.0056
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