Downregulation of DNA Methyltransferase 1 in Zona-Free Cloned Buffalo (Bubalus bubalis) Embryos by Small Interefering RNA Improves In Vitro Development But Does Not Alter DNA Methylation Level

Aberrant epigenetic reprogramming, especially genomic hypermethylation, is implicated as the primary reason behind the failure of the cloning process during somatic cell nuclear transfer (SCNT). We transfected one-cell-stage zona-free buffalo embryos produced by handmade cloning with 50 nM DNMT1 sma...

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Detalhes bibliográficos
Publicado no:Cell Reprogram
Principais autores: Selokar, Naresh L., Saini, Monika, Agrawal, Himanshu, Palta, Prabhat, Chauhan, Manmohan S., Manik, Radheysham, Singla, Suresh K.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378840/
https://ncbi.nlm.nih.gov/pubmed/25826721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cell.2014.0056
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