Selection and identification of ligand peptides targeting a model of castrate-resistant osteogenic prostate cancer and their receptors

We performed combinatorial peptide library screening in vivo on a novel human prostate cancer xenograft that is androgen-independent and induces a robust osteoblastic reaction in bonelike matrix and soft tissue. We found two peptides, PKRGFQD and SNTRVAP, which were enriched in the tumors, targeted...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Mandelin, Jami, Cardó-Vila, Marina, Driessen, Wouter H. P., Mathew, Paul, Navone, Nora M., Lin, Sue-Hwa, Logothetis, Christopher J., Rietz, Anna Cecilia, Dobroff, Andrey S., Proneth, Bettina, Sidman, Richard L., Pasqualini, Renata, Arap, Wadih
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378428/
https://ncbi.nlm.nih.gov/pubmed/25762070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500128112
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