Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4(+) T cells, and disease progression

HIV-1 infection is characterized by varying degrees of chronic immune activation and disruption of T-cell homeostasis, which impact the rate of disease progression. A deeper understanding of the factors that influence HIV-1–induced immunopathology and subsequent CD4(+) T-cell decline is critical to...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Claiborne, Daniel T., Prince, Jessica L., Scully, Eileen, Macharia, Gladys, Micci, Luca, Lawson, Benton, Kopycinski, Jakub, Deymier, Martin J., Vanderford, Thomas H., Nganou-Makamdop, Krystelle, Ende, Zachary, Brooks, Kelsie, Tang, Jianming, Yu, Tianwei, Lakhi, Shabir, Kilembe, William, Silvestri, Guido, Douek, Daniel, Goepfert, Paul A., Price, Matthew A., Allen, Susan A., Paiardini, Mirko, Altfeld, Marcus, Gilmour, Jill, Hunter, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378387/
https://ncbi.nlm.nih.gov/pubmed/25730868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421607112
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