Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas

The GH/IGF1 response of somatotropinomas to somatostatin analogues (SSA) is associated with their pattern of somatostatin receptor (sst1–sst5) expression. Recently, we demonstrated that expression of a truncated sst5-variant (sst5TMD4) can influence the secretory response of somatotropinomas to SSA-...

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Veröffentlicht in:Cancer Lett
Hauptverfasser: Luque, Raúl M., Ibáñez-Costa, Alejandro, Neto, Leonardo Vieira, Taboada, Giselle F., Hormaechea-Agulla, Daniel, Kasuki, Leandro, Venegas-Moreno, Eva, Moreno-Carazo, Alberto, Gálvez, María Ángeles, Soto-Moreno, Alfonso, Kineman, Rhonda D., Culler, Michael D., Gahete, Manuel D., Gadelha, Mônica R., Castaño, Justo P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378269/
https://ncbi.nlm.nih.gov/pubmed/25637790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.01.037
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