Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation

Pancreatic ductal adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a “ductal-like” state during PanIN-PDA formation. Here, we demonstrate...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Roy, Nilotpal, Malik, Shivani, Villanueva, Karina E., Urano, Atsushi, Lu, Xinyuan, Von Figura, Guido, Seeley, E. Scott, Dawson, David W., Collisson, Eric A., Hebrok, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2015
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378197/
https://ncbi.nlm.nih.gov/pubmed/25792600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.256628.114
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