Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation

Pancreatic ductal adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a “ductal-like” state during PanIN-PDA formation. Here, we demonstrate...

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Vydáno v:Genes Dev
Hlavní autoři: Roy, Nilotpal, Malik, Shivani, Villanueva, Karina E., Urano, Atsushi, Lu, Xinyuan, Von Figura, Guido, Seeley, E. Scott, Dawson, David W., Collisson, Eric A., Hebrok, Matthias
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2015
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378197/
https://ncbi.nlm.nih.gov/pubmed/25792600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.256628.114
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