Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus

In many cells, mRNAs containing inverted repeated Alu elements (IRAlus) in their 3′ untranslated regions (UTRs) are inefficiently exported to the cytoplasm. Such nuclear retention correlates with paraspeckle-associated protein complexes containing p54(nrb). However, nuclear retention of mRNAs contai...

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Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Hu, Shi-Bin, Xiang, Jian-Feng, Li, Xiang, Xu, Yefen, Xue, Wei, Huang, Min, Wong, Catharine C., Sagum, Cari A., Bedford, Mark T., Yang, Li, Cheng, Donghang, Chen, Ling-Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2015
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378195/
https://ncbi.nlm.nih.gov/pubmed/25792598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.257048.114
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