Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells.

The mechanisms that regulate insulin secretion were investigated using capacitance measurements of exocytosis in single beta cells maintained in tissue culture. Exocytosis was stimulated by voltage-clamp depolarizations to activate the voltage-dependent Ca2+ channels that mediate Ca2+ influx into th...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Ammälä, C, Eliasson, L, Bokvist, K, Berggren, P O, Honkanen, R E, Sjöholm, A, Rorsman, P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43781/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8183910/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.10.4343
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