MicroRNA-21 in Glomerular Injury

TGF-β(1) is a pleotropic growth factor that mediates glomerulosclerosis and podocyte apoptosis, hallmarks of glomerular diseases. The expression of microRNA-21 (miR-21) is regulated by TGF-β(1), and miR-21 inhibits apoptosis in cancer cells. TGF-β(1)–transgenic mice exhibit accelerated podocyte loss...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: Lai, Jennifer Y., Luo, Jinghui, O’Connor, Christopher, Jing, Xiaohong, Nair, Viji, Ju, Wenjun, Randolph, Ann, Ben-Dov, Iddo Z., Matar, Regina N., Briskin, Daniel, Zavadil, Jiri, Nelson, Robert G., Tuschl, Thomas, Brosius, Frank C., Kretzler, Matthias, Bitzer, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2015
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378097/
https://ncbi.nlm.nih.gov/pubmed/25145934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013121274
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