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Chemotherapy stimulates syndecan-1 shedding: A potentially negative effect of treatment that may promote tumor relapse

In patients with multiple myeloma, the heparan sulfate proteoglycan syndecan-1 (CD138) is shed from the surface of tumor cells and accumulates in the serum and within the extracellular matrix of the bone marrow where it promotes tumor growth and metastasis. In the present study we discovered that co...

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Dettagli Bibliografici
Pubblicato in:Matrix Biol
Autori principali: Ramani, Vishnu C., Sanderson, Ralph D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377822/
https://ncbi.nlm.nih.gov/pubmed/24145151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2013.10.005
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