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Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome

Introns are removed from nuclear messenger RNA precursors through two sequential phospho-transesterification reactions in a dynamic RNA–protein complex called the spliceosome(1,2). But whether splicing is catalysed by small nuclear RNAs(3,4) in the spliceosome is unresolved. As the spliceosome is a...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Yean, Shyue-Lee, Wuenschell, Gerald, Termini, John, Lin, Ren-Jang
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377090/
https://ncbi.nlm.nih.gov/pubmed/11130730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/35048617
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