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Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome
Introns are removed from nuclear messenger RNA precursors through two sequential phospho-transesterification reactions in a dynamic RNA–protein complex called the spliceosome(1,2). But whether splicing is catalysed by small nuclear RNAs(3,4) in the spliceosome is unresolved. As the spliceosome is a...
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| Pubblicato in: | Nature |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4377090/ https://ncbi.nlm.nih.gov/pubmed/11130730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/35048617 |
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