Endothelial PPARγ Protects Against Vascular Thrombosis by Downregulating P-Selectin Expression

OBJECTIVE: We tested the hypothesis that endothelial proliferator-activated receptor-gamma (PPARγ) protects against vascular thrombosis using a transgenic mouse model expressing a PPARγ mutant (E-V290M) selectively in endothelium. APPROACH AND RESULTS: The time to occlusive thrombosis of the carotid...

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Udgivet i:Arterioscler Thromb Vasc Biol
Main Authors: Jin, Hong, Gebska, Milena A., Blokhin, Ilya O., Wilson, Katina M., Ketsawatsomkron, Pimonrat, Chauhan, Anil K., Keen, Henry L., Sigmund, Curt D., Lentz, Steven R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376629/
https://ncbi.nlm.nih.gov/pubmed/25675995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.305378
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