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An RNA Aptamer Specific to Hsp70-ATP Conformation Inhibits its ATPase Activity Independent of Hsp40
The highly conserved and ubiquitous molecular chaperone heat shock protein 70 (Hsp70) plays a critical role in protein homeostasis (proteostasis). Controlled by its ATPase activity, Hsp70 cycles between two conformations, Hsp70-ATP and Hsp70-ADP, to bind and release its substrate. Chemical tools wit...
Shranjeno v:
| izdano v: | Nucleic Acid Ther |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Mary Ann Liebert, Inc.
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4376485/ https://ncbi.nlm.nih.gov/pubmed/25654640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2014.0510 |
| Oznake: |
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