Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides

Oligonucleotide analogs have provided novel therapeutics targeting various disorders. However, their poor cellular uptake remains a major obstacle for their clinical development. Negatively charged oligonucleotides, such as 2′-O-Methyl RNA and locked nucleic acids have in recent years been delivered...

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Detalhes bibliográficos
Publicado no:Nucleic Acid Ther
Main Authors: Järver, Peter, Zaghloul, Eman M., Arzumanov, Andrey A., Saleh, Amer F., McClorey, Graham, Hammond, Suzan M., Hällbrink, Mattias, Langel, Ülo, Smith, C.I. Edvard, Wood, Matthew J.A., Gait, Michael J., EL Andaloussi, Samir
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376484/
https://ncbi.nlm.nih.gov/pubmed/25594433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2014.0511
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