Melatonin–sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a ‘drug–prodrug’ mechanism of action

BACKGROUND AND PURPOSE: Neurodegenerative diseases are a major problem afflicting ageing populations; however, there are no effective treatments to stop their progression. Oxidative stress and neuroinflammation are common factors in their pathogenesis. Nuclear factor (erythroid-derived 2)-like 2 (Nr...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Egea, Javier, Buendia, Izaskun, Parada, Esther, Navarro, Elisa, Rada, Patricia, Cuadrado, Antonio, López, Manuela G, García, Antonio G, León, Rafael
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2015
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376458/
https://ncbi.nlm.nih.gov/pubmed/25425158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13025
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