Ionizing radiation, inflammation, and their interactions in colon carcinogenesis in Mlh1-deficient mice

Genetic, physiological and environmental factors are implicated in colorectal carcinogenesis. Mutations in the mutL homolog 1 (MLH1) gene, one of the DNA mismatch repair genes, are a main cause of hereditary colon cancer syndromes such as Lynch syndrome. Long-term chronic inflammation is also a key...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Morioka, Takamitsu, Miyoshi-Imamura, Tomoko, Blyth, Benjamin J, Kaminishi, Mutsumi, Kokubo, Toshiaki, Nishimura, Mayumi, Kito, Seiji, Tokairin, Yutaka, Tani, Shusuke, Murakami-Murofushi, Kimiko, Yoshimi, Naoki, Shimada, Yoshiya, Kakinuma, Shizuko
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376429/
https://ncbi.nlm.nih.gov/pubmed/25529563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12591
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