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Structural Characterization of O- and C-Glycosylating Variants of the Landomycin Glycosyltransferase LanGT2()
The structures of the O-glycosyltransferase LanGT2 and the engineered, C—C bond-forming variant LanGT2S8Ac show how the replacement of a single loop can change the functionality of the enzyme. Crystal structures of the enzymes in complex with a nonhydrolyzable nucleotide-sugar analogue revealed that...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4376353/ https://ncbi.nlm.nih.gov/pubmed/25581707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201409792 |
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