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Generation of New Landomycins with Altered Saccharide Patterns through Over-expression of the Glycosyltransferase Gene lanGT3 in the Biosynthetic Gene Cluster of Landomycin A in Streptomyces cyanogenus S-136

Two novel landomycin compounds, landomycins I and J, were generated with a new mutant strain of Streptomyces cyanogenus in which the glycosyltransferase that is encoded by lanGT3 was over-expressed. This mutant also produced the known landomycins A, B, and D. All these compounds consist ofthe same p...

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Main Authors: Zhu, Lili, Luzhetskyy, Andriy, Luzhetska, Martha, Mattingly, Cynthia, Adams, Val, Bechthold, Andreas, Rohr, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879348/
https://ncbi.nlm.nih.gov/pubmed/17139690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200600360
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