Design and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives

Factor IXa (FIXa), a blood coagulation factor, is specifically inhibited at the initiation stage of the coagulation cascade, promising an excellent approach for developing selective and safe anticoagulants. Eighty-four amidinobenzothiophene antithrombotic derivatives targeting FIXa were selected to...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Gao, Jia-Suo, Tong, Xu-Peng, Chang, Yi-Qun, He, Yu-Xuan, Mei, Yu-Dan, Tan, Pei-Hong, Guo, Jia-Liang, Liao, Guo-Chao, Xiao, Gao-Keng, Chen, Wei-Min, Zhou, Shu-Feng, Sun, Ping-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376188/
https://ncbi.nlm.nih.gov/pubmed/25848211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S75282
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