Novel Cycloheximide Derivatives Targeting the Moonlighting Protein Mip Exhibit Specific Antimicrobial Activity Against Legionella pneumophila

Macrophage infectivity potentiator (Mip) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of peptidyl-prolyl-cis/trans-isomerases (PPIases). In L. pneumophila, the PPIase activi...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Main Authors: Rasch, Janine, Theuerkorn, Martin, Ünal, Can, Heinsohn, Natascha, Tran, Stefan, Fischer, Gunter, Weiwad, Matthias, Steinert, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Bioengineering and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376002/
https://ncbi.nlm.nih.gov/pubmed/25870856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2015.00041
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