Mammalian Polo-like Kinase 1 (Plk1) Promotes Proper Chromosome Segregation by Phosphorylating and Delocalizing the PBIP1·CENP-Q Complex from Kinetochores

Mammalian Plk1 is critically required for proper M phase progression. Plk1 is self-recruited to prekinetochores/kinetochores by phosphorylating and binding to the Thr-78 motif of a kinetochore scaffold protein, PBIP1 (also called CENP-U/50), which forms a stable complex with another kinetochore comp...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Park, Chi Hoon, Park, Jung-Eun, Kim, Tae-Sung, Kang, Young Hwi, Soung, Nak-Kyun, Zhou, Ming, Kim, Nam-Hyung, Bang, Jeong Kyu, Lee, Kyung S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375506/
https://ncbi.nlm.nih.gov/pubmed/25670858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.623546
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