A Mechanism of Global Shape-dependent Recognition and Phosphorylation of Filamin by Protein Kinase A

Protein phosphorylation mediates essentially all aspects of cellular life. In humans, this is achieved by ∼500 kinases, each recognizing a specific consensus motif (CM) in the substrates. The majority of CMs are surface-exposed and are thought to be accessible to kinases for phosphorylation. Here we...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ithychanda, Sujay Subbayya, Fang, Xianyang, Mohan, Maradumane L., Zhu, Liang, Tirupula, Kalyan C., Naga Prasad, Sathyamangla V., Wang, Yun-Xing, Karnik, Sadashiva S., Qin, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375502/
https://ncbi.nlm.nih.gov/pubmed/25666618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.633446
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