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Functional Significance of Point Mutations in Stress Chaperone Mortalin and Their Relevance to Parkinson Disease
Mortalin/mtHsp70/Grp75 (mot-2), a heat shock protein 70 family member, is an essential chaperone, enriched in cancers, and has been shown to possess pro-proliferative and anti-apoptosis functions. An allelic form of mouse mortalin (mot-1) that differs by two amino acids, M618V and G624R, in the C te...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375496/ https://ncbi.nlm.nih.gov/pubmed/25645922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627463 |
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