Arresting Amyloid with Coulomb’s Law: Acetylation of ALS-Linked SOD1 by Aspirin Impedes Aggregation

Although the magnitude of a protein’s net charge (Z) can control its rate of self-assembly into amyloid, and its interactions with cellular membranes, the net charge of a protein is not viewed as a druggable parameter. This article demonstrates that aspirin (the quintessential acylating pharmacon) c...

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Bibliographische Detailangaben
Veröffentlicht in:Biophys J
Hauptverfasser: Abdolvahabi, Alireza, Shi, Yunhua, Rhodes, Nicholas R., Cook, Nathan P., Martí, Angel A., Shaw, Bryan F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2015
Schlagworte:
Proteins and Nucleic Acids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375441/
https://ncbi.nlm.nih.gov/pubmed/25762331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.01.014
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