Global Biochemical Profiling Identifies β-Hydroxypyruvate as a Potential Mediator of Type 2 Diabetes in Mice and Humans

Glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 are incretins secreted by respective K and L enteroendocrine cells after eating and amplify glucose-stimulated insulin secretion (GSIS). This amplification has been termed the “incretin response.” To determine the role(s) of K cells for th...

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Dettagli Bibliografici
Pubblicato in:Diabetes
Autori principali: Zhang, Sheng, Wang, Songyan, Puhl, Matthew D., Jiang, Xuntian, Hyrc, Krzysztof L., Laciny, Erin, Wallendorf, Michael J., Pappan, Kirk L., Coyle, Joseph T., Wice, Burton M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2015
Soggetti:
Pathophysiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375086/
https://ncbi.nlm.nih.gov/pubmed/25368100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1188
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