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Untargeted metabolomics identifies unique though benign biochemical changes in patients with pathogenic variants in UROC1

Urocanic aciduria is caused by a deficiency in the enzyme urocanase (E.C. 4.2.1.49) encoded by the gene UROC1. In the past, deficiency of urocanase has been associated with intellectual disability in a few case studies with some suggestion that the enzyme deficiency was the causative etiology. Here,...

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Detalhes bibliográficos
Publicado no:Mol Genet Metab Rep
Main Authors: Glinton, Kevin E., Levy, Harvey L., Kennedy, Adam D., Pappan, Kirk L., Elsea, Sarah H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312870/
https://ncbi.nlm.nih.gov/pubmed/30619714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgmr.2018.12.005
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