Noncanonical Wnt Signaling Promotes Obesity-Induced Adipose Tissue Inflammation and Metabolic Dysfunction Independent of Adipose Tissue Expansion

Adipose tissue dysfunction plays a pivotal role in the development of insulin resistance in obese individuals. Cell culture studies and gain-of-function mouse models suggest that canonical Wnt proteins modulate adipose tissue expansion. However, no genetic evidence supports a role for endogenous Wnt...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Fuster, José J., Zuriaga, María A., Ngo, Doan Thi-Minh, Farb, Melissa G., Aprahamian, Tamar, Yamaguchi, Terry P., Gokce, Noyan, Walsh, Kenneth
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2015
Assuntos:
Obesity Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375084/
https://ncbi.nlm.nih.gov/pubmed/25352637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1164
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