Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipimox, an NAD(+) precursor, would directly aff...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: van de Weijer, Tineke, Phielix, Esther, Bilet, Lena, Williams, Evan G., Ropelle, Eduardo R., Bierwagen, Alessandra, Livingstone, Roshan, Nowotny, Peter, Sparks, Lauren M., Paglialunga, Sabina, Szendroedi, Julia, Havekes, Bas, Moullan, Norman, Pirinen, Eija, Hwang, Jong-Hee, Schrauwen-Hinderling, Vera B., Hesselink, Matthijs K.C., Auwerx, Johan, Roden, Michael, Schrauwen, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375076/
https://ncbi.nlm.nih.gov/pubmed/25352640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0667
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