Toll-Like Receptor 4 Promotes Autonomic Dysfunction, Inflammation and Microglia Activation in the Hypothalamic Paraventricular Nucleus: Role of Endoplasmic Reticulum Stress

BACKGROUND & PURPOSE: Toll-like receptor 4 (TLR4) signaling induces tissue pro-inflammatory cytokine release and endoplasmic reticulum (ER) stress. We examined the role of TLR4 in autonomic dysfunction and the contribution of ER stress. EXPERIMENTAL APPROACH: Our study included animals divided i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Masson, Gustavo S., Nair, Anand R., Dange, Rahul B., Silva-Soares, Pedro Paulo, Michelini, Lisete C., Francis, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374971/
https://ncbi.nlm.nih.gov/pubmed/25811788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122850
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