Hepatocyte- Specific Deletion of ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator) Results in Altered Fibrotic Gene Expression in the Thioacetamide Model of Liver Injury

BACKGROUND & AIMS: Recent studies have shown that increased expression of liver hypoxia inducible factor 2-α (HIF-2α) leads to liver inflammation and a pro-fibrotic gene expression signature. Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) is required for HIF-2α transcriptional activity an...

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Veröffentlicht in:PLoS One
Hauptverfasser: Scott, Christopher, Cha, Kuan, Rao, Renuka, Liddle, Christopher, George, Jacob, Gunton, Jenny E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374875/
https://ncbi.nlm.nih.gov/pubmed/25812120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121650
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