Epigenetic Inactivation of RASSF1A in Lung and Breast Cancers and Malignant Phenotype Suppression

BACKGROUND: The recently identified RASSF1 locus is located within a 120-kilobase region of chromosome 3p21.3 that frequently undergoes allele loss in lung and breast cancers. We explored the hypothesis that RASSF1 encodes a tumor suppressor gene for lung and breast cancers. METHODS: We assessed exp...

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Publicado en:J Natl Cancer Inst
Autores principales: Burbee, David G., Forgacs, Eva, Zöchbauer-Müller, Sabine, Shivakumar, Latha, Fong, Kwun, Gao, Boning, Randle, Dwight, Kondo, Masashi, Virmani, Arvind, Bader, Scott, Sekido, Yoshitaka, Latif, Farida, Milchgrub, Sara, Toyooka, Shinichi, Gazdar, Adi F., Lerman, Michael I., Zabarovsky, Eugene, White, Michael, Minna, John D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2001
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374741/
https://ncbi.nlm.nih.gov/pubmed/11333291
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