The RASSF1A Tumor Suppressor Blocks Cell Cycle Progression and Inhibits Cyclin D1 Accumulation

The RASSF1A locus at 3p21.3 is epigenetically inactivated at high frequency in a variety of solid tumors. Expression of RASSF1A is sufficient to revert the tumorigenicity of human cancer cell lines. We show here that RASSF1A can induce cell cycle arrest by engaging the Rb family cell cycle checkpoin...

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Detalhes bibliográficos
Main Authors: Shivakumar, Latha, Minna, John, Sakamaki, Toshiyuki, Pestell, Richard, White, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133879/
https://ncbi.nlm.nih.gov/pubmed/12024041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.12.4309-4318.2002
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