The RASSF1A Tumor Suppressor Blocks Cell Cycle Progression and Inhibits Cyclin D1 Accumulation

The RASSF1A locus at 3p21.3 is epigenetically inactivated at high frequency in a variety of solid tumors. Expression of RASSF1A is sufficient to revert the tumorigenicity of human cancer cell lines. We show here that RASSF1A can induce cell cycle arrest by engaging the Rb family cell cycle checkpoin...

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Hlavní autoři: Shivakumar, Latha, Minna, John, Sakamaki, Toshiyuki, Pestell, Richard, White, Michael A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC133879/
https://ncbi.nlm.nih.gov/pubmed/12024041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.12.4309-4318.2002
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