Structural Models of Zebrafish (Danio rerio) NOD1 and NOD2 NACHT Domains Suggest Differential ATP Binding Orientations: Insights from Computational Modeling, Docking and Molecular Dynamics Simulations

Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) and NOD2 are cytosolic pattern recognition receptors playing pivotal roles in innate immune signaling. NOD1 and NOD2 recognize bacterial peptidoglycan derivatives iE-DAP and MDP, respectively and undergoes conformational alternati...

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Udgivet i:PLoS One
Main Authors: Maharana, Jitendra, Sahoo, Bikash Ranjan, Bej, Aritra, Jena, Itishree, Parida, Arunima, Sahoo, Jyoti Ranjan, Dehury, Budheswar, Patra, Mahesh Chandra, Martha, Sushma Rani, Balabantray, Sucharita, Pradhan, Sukanta Kumar, Behera, Bijay Kumar
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374677/
https://ncbi.nlm.nih.gov/pubmed/25811192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121415
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