Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain

NOD2 activation by muramyl dipeptide causes a proinflammatory immune response in which the adaptor protein CARD9 works synergistically with NOD2 to drive p38 and c-Jun N-terminal kinase (JNK) signalling. To date the nature of the interaction between NOD2 and CARD9 remains undetermined. Here we show...

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Detalhes bibliográficos
Main Authors: Parkhouse, Rhiannon, Boyle, Joseph P., Mayle, Sophie, Sawmynaden, Kovilen, Rittinger, Katrin, Monie, Tom P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons Ltd 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158416/
https://ncbi.nlm.nih.gov/pubmed/24960071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.06.035
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