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Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways
BACKGROUND: High levels of thymidine kinase 1 (TK1) and thymidine phosphorylase (TYMP) are key molecular targets by thymidine therapeutics in cancer treatment. The dual roles of TYMP as a tumor growth factor and a key activation enzyme of anticancer metabolites resulted in a mixed outcome in cancer...
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| Publicado no: | BMC Cancer |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4374574/ https://ncbi.nlm.nih.gov/pubmed/25881156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1149-5 |
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